The enzyme phosphoserine phosphatase (EC 3.1.3.3)
catalyzes the reaction
:''O''-phospho-
L(or
D)-serine + H
2O
L(or
D)-serine +
phosphate
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid .
The phosphate or orthophosphate ion is derived from phosph ...
This enzyme belongs to the family of
hydrolases, specifically those acting on phosphoric
monoester bonds. The
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
is ''O''-
phosphoserine phosphohydrolase. This enzyme participates in
glycine
Glycine (symbol Gly or G; ) is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid ( carbamic acid is unstable), with the chemical formula NH2‐ CH2‐ COOH. Glycine is one of the proteinog ...
,
serine
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α- amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − for ...
and
threonine metabolism
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), a carboxyl group (which is in the deprotonated −COO ...
.
Structural studies
As of late 2007, 12
structures have been solved for this class of enzymes, with
PDB accession codes , , , , , , , , , , , and .
References
*
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
*
EC 3.1.3
Enzymes of known structure
{{3.1-enzyme-stub